Erythrocyte Inclusions - Wright Stained Smears (Online CEU Course)
Marjorie A. Spahn, MT (ASCP); Marybeth Fannon, MA, MT (ASCP)
This course describes and richly illustrates various erythrocyte inclusions, including basophilic stippling, Cabot rings, Pappenheimer bodies, siderotic granules, and Howell-Jolly bodies, making it productive for CE, exam reviewing, and cross training.
Continuing Education Credits
- P.A.C.E.® Contact Hours (acceptable for AMT, ACSP / NCA, and state recertification): 2.5 hour(s)
- Florida Board of Clinical Laboratory Science CE - General (Hematology): 2.5 hour(s)
Objectives
- Define the term erythrocyte inclusion.
- Explain why it is important to identify erythrocyte inclusions.
- Discuss: reticulocytes (polychromasia), basophilic stippling, and Cabot rings with respect to: stain used, appearance, composition, and associated physiological defects.
- Discuss: Pappenheimer bodies, siderotic granules, and Howell-Jolly bodies with respect to: stain used, appearance, composition, and associated physiological defects.
- Discuss the use of Perl's Prussian blue iron stain to confirm the presence of iron containing granules.
- Identify erythrocyte inclusions that may be present on a peripheral blood smear.
Course Outline
Click on a link in the outline to view a sample page from this course.
- Introduction to Erythrocyte Inclusions
- Characteristics of Reticulocytes (Polychromasia)
- Reticulocytes
- More on Reticulocytes
- Erythrocyte Production
- Stress Reticulocytes
- Normal Red Cells
- Polychromatophilic Cells
- Another Polychromatophilic Cell
- Which of the following statements characterize a reticulocyte? (Choose ALL of the correct answers)
- On a Wright's-stained smear, the blue/gray appearing non-nucleated red cells are called:
- The presence of shift reticulocytes is an indication that red cells are leaving the marrow earlier t
- This slide contains:
- Characteristics of Basophilic Stippling
- What is Basophilic Stippling?
- More on Basophilic Stippling
- Fine and Coarse Basophilic Stippling
- Basophilic Stippling
- Coarse Basophilic Stippling
- Another Coarse Basophilic Stippling
- What is the composition of basophilic stippling?
- What kind of bone marrow activity is associated with fine basophilic stippling?
- Disorders in which coarse basophilic stippling can be seen are: (Choose ALL of the correct answers)
- The cells in this slide show:
- The abnormalities that are seen on this slide are probably associated with which of the following conditions?
- Characteristics of Howell-Jolly Bodies
- What are Howell-Jolly Bodies?
- More on Howell-Jolly Bodies
- Howell-Jolly Body
- Another Howell-Jolly Body
- Howell-Jolly Bodies in Cytoplasm
- What is the composition of Howell-Jolly bodies?
- If present, how many Howell-Jolly bodies are usually seen within each erythrocyte?
- In which of the following conditions would you expect to find Howell-Jolly bodies?
- What abnormality is indicated by the arrow on this slide?
- What erythrocyte abnormality is present on this slide?
- What abnormality is present in this slide?
- Characteristics of Pappenheimer bodies and Siderotic granules
- What are Pappenheimer bodies?
- More on Pappenheimer bodies
- Cells Containing Pappenheimer Bodies
- Basophilic Stippling contrasted with Pappenheimer Bodies
- Howell-Jolly bodies and Pappenheimer bodies
- Comparison of Erythrocyte Inclusions
- Siderotic Granules
- Siderocytes and Ring Sideroblasts.
- Siderocytes
- Sideroblast
- Ringed Sideroblast
- Siderotic Granules
- Which of the following statements best describes Pappenheimer bodies?
- In a Wright's-stained smear, Pappenheimer bodies must be differentiated from basophilic stippling a
- Match the following terms with the correct definition.
- What is the reason for using Perl's Prussian blue stain?
- In which of the following conditions are Pappenheimer bodies and siderocytes seen on the peripheral
- Which of the following is considered a pathological finding?
- This smear shows:
- This smear shows Pappenheimer bodies.
- Which of the following terms most accurately identifies the cell indicated by the arrow in this Prussian blue-stained bone marrow smear?
- The cells indicated by the arrows are polychromatophilic red blood cells.
- The red cell in the center of the field contains a:
- Characteristics of Cabot Rings
- What are Cabot rings?
- Cabot Rings
- Cabot Ring Example
- Cabot Ring Impersonation
- Which of the following statements best describes the appearance of Cabot rings?
- Identify the conditions in which Cabot rings are occasionally seen.
Additional Information
Level of Instruction: Basic
Intended Audience: Medical laboratory science students, medical technologists and MLTs requiring review or cross training, pathology residents.
Course Description: This course explains and illustrates red cell inclusions seen in peripheral smears, in particular Howell-Jolly bodies, Pappenheimer bodies, polychromasia, basophilic stippling, and Cabot rings. Numerous practice and exam questions reinforce visual recognition skills.
About this Course: This course is part of a series of courses adapted for the web by MediaLab Inc. under license from Educational Materials for Health Professionals Inc. Dayton OH, 45420. Copyright EMHP Inc.
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